I find plenty of irony in Frankenstein concerning how Nature is punishing him for his creation. Victor Frankenstein betrayed Nature by creating life. He seemed to try to usurp the power of Nature. How Nature punishes him is by showing him that life should remain in the control of Nature. It is ironic because to demonstrate how Nature believes that Victor, a creature under its control, betrayed it is by having Frankenstein's Monster, a creature under Victor's control, betray him. Victor Frankenstein believes that he has the right to decide life and death, and therefore brings a monstrosity to life. His monster also believes that it has the right to decide life and death, and therefore drains the life of Victor's young brother. In most stories, when Nature retaliates, it uses thunder, lightning, natural disasters, etc. This brand of retaliation can be found in the "Rime of the Ancient Mariner." The mariner experiences devastating weather that accompanies the death of all of his shipmates. However, in Frankenstein, Nature can just sit back and watch Frankenstein's creation punish him for his actions.
Frankenstein gave life to this creature, just as Nature gave life to Victor Frankenstein. Nature does not actually have any power over Frankenstein's Monster, as it did not create or give life to the monster. Therefore, all of the punishment for its unfortunate existence that can be doled out by nature must fall squarely on Vicor's shoulders. Nature is definitely a force to be reckoned with, and Victor went against Nature's power; therefore, Nature demostrates just how ungrateful a creature can act towards its creator.
